Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice.

@article{Zhang2012CurcuminPA,
  title={Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice.},
  author={Lin Zhang and Tianyuan Xu and Shuang Wang and Lanqing Yu and Dexiang Liu and Renzhi Zhan and Shu-Yan Yu},
  journal={Behavioural brain research},
  year={2012},
  volume={235 1},
  pages={67-72}
}
The potential antidepressant effects of curcumin have been demonstrated in various animal models of depression, however, there is little information regarding the site and mechanisms of curcumin in promoting antidepressant effects. The present study attempts to explore the mechanisms underlying the antidepressant-like action of curcumin by measuring the contents of brain derived neurotrophic factor (BDNF) in the amygdala of animal model of depression. The results showed that treatment with… CONTINUE READING