Curcumin nanoparticles attenuate cardiac remodeling due to pulmonary arterial hypertension.

@article{Rice2016CurcuminNA,
  title={Curcumin nanoparticles attenuate cardiac remodeling due to pulmonary arterial hypertension.},
  author={Kevin M. Rice and Nandini D. P. K. Manne and Madhukar B. Kolli and Paulette S Wehner and Lucy Dornon and Ravikumar Arvapalli and Vellaisamy Selvaraj and Arun Kumar and Eric Blough},
  journal={Artificial cells, nanomedicine, and biotechnology},
  year={2016},
  volume={44 8},
  pages={1909-1916}
}
Herein, we investigate whether curcumin nanoparticles (Cur NPs) are effective for the treatment of monocrotaline (MCT)-induced pulmonary arterial hypertension in Sprague Dawley rat. Echocardiography was performed at the start of the study and 28 days after MCT injection. Compared to MCT only animals, Cur NP administration was associated with reduced right ventricular (RV) wall thickness and a decreased right ventricle weight/body weight ratio. Cur NPs also attenuated MCT induced increase in RV… CONTINUE READING

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