Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with hypoxic-ischemic encephalopathy

@article{Joseph2018CurcuminloadedPN,
  title={Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with hypoxic-ischemic encephalopathy},
  author={Andrea A. Joseph and Thomas Ragnar Wood and Chih-Chung Chen and Kylie A. Corry and Jessica M Snyder and Sandra E Juul and Pratik Parikh and Elizabeth Nance},
  journal={Nano Research},
  year={2018},
  volume={11},
  pages={5670-5688}
}
  • Andrea A. Joseph, Thomas Ragnar Wood, +5 authors Elizabeth Nance
  • Published in Nano Research 2018
  • Materials Science
  • Hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Inflammatory processes play a key role in the progression of this disease and may be amenable to a targeted pharmaceutical intervention. Curcumin is a dietary compound with potent anti-inflammatory, antioxidant, and antiapoptotic properties but is limited in therapeutic applications due to its low aqueous solubility, low bioavailability, and rapid first-pass hepatic… CONTINUE READING

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