Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo.

@article{Gou2011CurcuminloadedBP,
  title={Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo.},
  author={Maling Gou and Ke Men and Huashan Shi and Mingli Xiang and Juan Zhang and J. -G. Song and Jianlin Long and Yang Wan and Feng Luo and Xia Zhao and Zhiyong Qian},
  journal={Nanoscale},
  year={2011},
  volume={3 4},
  pages={1558-67}
}
Curcumin is an effective and safe anticancer agent, but its hydrophobicity inhibits its clinical application. Nanotechnology provides an effective method to improve the water solubility of hydrophobic drug. In this work, curcumin was encapsulated into monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles through a single-step nano-precipitation method, creating curcumin-loaded MPEG-PCL (Cur/MPEG-PCL) micelles. These Cur/MPEG-PCL micelles were monodisperse (PDI = 0.097 ± 0… CONTINUE READING