Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.

@article{Milacic2008CurcuminIT,
  title={Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.},
  author={Vesna Milacic and S Preeya Banerjee and Kristin R. Landis-Piwowar and Fazlul H. Sarkar and Adhip P. N. Majumdar and Q Ping Dou},
  journal={Cancer research},
  year={2008},
  volume={68 18},
  pages={7283-92}
}
Curcumin (diferuloylmethane) is the major active ingredient of turmeric (Curcuma longa) used in South Asian cuisine for centuries. Curcumin has been shown to inhibit the growth of transformed cells and to have a number of potential molecular targets. However, the essential molecular targets of curcumin under physiologic conditions have not been completely defined. Herein, we report that the tumor cellular proteasome is most likely an important target of curcumin. Nucleophilic susceptibility and… CONTINUE READING
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