Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells.

@article{Beevers2006CurcuminIT,
  title={Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells.},
  author={Christopher Sean Beevers and Fengjun Li and Lei Liu and Shile Huang},
  journal={International journal of cancer},
  year={2006},
  volume={119 4},
  pages={
          757-64
        }
}
Curcumin (diferuloylmethane), a polyphenol natural product of the plant Curcuma longa, is undergoing early clinical trials as a novel anticancer agent. However, the anticancer mechanism of curcumin remains to be elucidated. Here we show that curcumin inhibited growth of rhabdomyosarcoma cells (Rh1 and Rh30) (IC50 = 2-5 microM) and arrested cells in G1 phase of the cell cycle. Curcumin also induced apoptosis and inhibited the basal or type I insulin-like growth factor-induced motility of the… CONTINUE READING
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