Curcumin inhibits the mammalian target of rapamycin‐mediated signaling pathways in cancer cells

@article{Beevers2006CurcuminIT,
  title={Curcumin inhibits the mammalian target of rapamycin‐mediated signaling pathways in cancer cells},
  author={Christopher S Beevers and Fengjun Li and Lei Liu and Shile Huang},
  journal={International Journal of Cancer},
  year={2006},
  volume={119}
}
Curcumin (diferuloylmethane), a polyphenol natural product of the plant Curcuma longa, is undergoing early clinical trials as a novel anticancer agent. However, the anticancer mechanism of curcumin remains to be elucidated. Here we show that curcumin inhibited growth of rhabdomyosarcoma cells (Rh1 and Rh30) (IC50 = 2–5 μM) and arrested cells in G1 phase of the cell cycle. Curcumin also induced apoptosis and inhibited the basal or type I insulin‐like growth factor‐induced motility of the cells… Expand
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TLDR
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Curcumin Induces Apoptosis in Human Neuroblastoma Cells via Inhibition of NFκB
TLDR
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