Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells

@article{Elamin2010CurcuminIT,
  title={Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells},
  author={Maha Hussein Elamin and Zakia Shinwari and Siti-Faujiah Hendrayani and Hindi N. Al-Hindi and Essam Al-Shail and Yasser M Khafaga and Amani A Al-Kofide and Abdelilah Aboussekhra},
  journal={Molecular Carcinogenesis},
  year={2010},
  volume={49}
}
Medulloblastoma is an aggressive primary brain tumor that arises in the cerebellum of children and young adults. The Sonic Hedgehog (Shh) signaling pathway that plays important roles in the pathology of this aggressive disease is a promising therapeutic target. In the present report we have shown that curcumin has cytotoxic effects on medulloblastoma cells. Curcumin suppressed also cell proliferation and triggered cell‐cycle arrest at G2/M phase. Moreover, curcumin inhibited the Shh–Gli1… Expand
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