Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.

@article{Khaw2013CurcuminIT,
  title={Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.},
  author={Aik Kia Khaw and Mollamemisoglu Hande and Guruprasad Kalthur and Manoor Prakash Hande},
  journal={Journal of cellular biochemistry},
  year={2013},
  volume={114 6},
  pages={1257-70}
}
Curcumin, a polyphenolic compound isolated from Curcuma longa (Turmeric) is widely used in traditional Ayurvedic medicine. Its potential therapeutic effects on a variety of diseases have long been known. Though anti-tumour effects of curcumin have been reported earlier, its mode of action and telomerase inhibitory effects are not clearly determined in brain tumour cells. In the present study, we demonstrate that curcumin binds to cell surface membrane and infiltrates into cytoplasm to initiate… CONTINUE READING
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