Curcumin inhibits suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.

@article{Zhao2012CurcuminIS,
  title={Curcumin inhibits suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.},
  author={Guang-Ju Zhao and Zhongqiu Lu and Lu-ming Tang and Zong-sheng Wu and Da-wei Wang and Jia-yi Zheng and Qiao-meng Qiu},
  journal={International immunopharmacology},
  year={2012},
  volume={14 1},
  pages={99-106}
}
Accumulating evidence has demonstrated that naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) are critical for maintenance of immunological tolerance and have been shown to be important in regulating the immune responses in many diseases. Curcumin, a phytochemical obtained from the rhizome of the plant Curcuma longa, has achieved the potential therapeutic interest to numerous immune-related disorders. However, the effect and mechanism of curcumin on Tregs remain largely elusive. In… CONTINUE READING