Curcumin inhibits paraquat induced lung inflammation and fibrosis by extracellular matrix modifications in mouse model

@article{Tyagi2016CurcuminIP,
  title={Curcumin inhibits paraquat induced lung inflammation and fibrosis by extracellular matrix modifications in mouse model},
  author={Namitosh Tyagi and D. Dash and Rashmi Singh},
  journal={Inflammopharmacology},
  year={2016},
  volume={24},
  pages={335-345}
}
ObjectiveParaquat (PQ), a potent herbicide can cause severe toxicity. We report here that fibroproliferation phase of acute lung injury (ALI) is initiated much earlier (within 48 h) after PQ intoxication than previously reported (after 2 weeks) and we aimed to study the protective effects of intranasal curcumin as new therapeutic strategy in mouse model.MethodsMice (Park's strain) were divided into five experimental groups (I) control, received only saline (0.9 % NaCl) (II) PQ, mice intoxicated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Lung extracellular matrix and fibroblast function.

  • Annals of the American Thoracic Society
  • 2015
VIEW 1 EXCERPT