Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways.

@article{Zhen2014CurcuminIO,
  title={Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways.},
  author={Lei Zhen and Desheng Fan and Xianghua Yi and Xinming Cao and Dong Chen and Liming Wang},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 10},
  pages={6438-46}
}
Epidermal growth factor receptor (EGFR) is an effective molecular target of anti-cancer therapies. Curcumin is known to inhibit growth, invasion and metastasis by downregulating EGFR expression in some cancer cells. However, the mechanism underlying the effect of curcumin in human oral squamous cell carcinoma (OSCC) remains unclear. In this study, we investigated the efficacy of curcumin on proliferation and invasion in SCC-25 cell line. We also explored the effect of curcumin on the activition… CONTINUE READING