Curcumin inhibits activation induced by urban particulate material or titanium dioxide nanoparticles in primary human endothelial cells

@article{MontielDvalos2017CurcuminIA,
  title={Curcumin inhibits activation induced by urban particulate material or titanium dioxide nanoparticles in primary human endothelial cells},
  author={Angelica Montiel-D{\'a}valos and Guadalupe Jazmin Silva S{\'a}nchez and Elizabeth Huerta-Garc{\'i}a and Cristhiam Rueda-Romero and Giovanny Soca Chafre and Irma B Mitre-Aguilar and Ernesto Alfaro-Moreno and Jos{\'e} Pedraza-Chaverri and Rebeca L{\'o}pez-Marure},
  journal={PLoS ONE},
  year={2017},
  volume={12}
}
Curcumin has protective effects against toxic agents and shows preventive properties for various diseases. Particulate material with an aerodynamic diameter of ≤10 μm (PM10) and titanium dioxide nanoparticles (TiO2-NPs) induce endothelial dysfunction and activation. We explored whether curcumin is able to attenuate different events related to endothelial activation. This includes adhesion, expression of adhesion molecules and oxidative stress induced by PM10 and TiO2-NPs. Human umbilical vein… Expand
Effects of physiochemical characteristic of nano-sized TiO2 on the adhesion of monocytes to endothelial cells
Abstract Nano-sized titanium dioxide (TiO2) particles are produced on a large scale and are widely used. However, the effects of exposure to nano-sized TiO2 particles on the cardiovascular systemExpand
Titanate nanotubes at non-cytotoxic concentrations affect NO signaling pathway in human umbilical vein endothelial cells.
TLDR
The results showed that TiNTs were less effectively internalized into HUVECs compared with TiO2 NPs, but none of the NMs induced cytotoxicity or activation of endoplasmic reticulum (ER) stress biomarkers. Expand
Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells
TLDR
This review chose four commonly used nanometal oxides to discuss about the toxicity they produced, the function they affected, and the mechanisms on cardiovascular endothelial cells. Expand
Curcumin promotes oxidative stress, apoptosis and autophagy in H9c2 rat cardiomyoblasts
Curcumin, a polyphenol derived from Curcuma longa, has some adverse effects on heart; however, its toxic effects on cardiac cells are poorly understood. To evaluate the toxicity of curcumin on H9c2Expand
Can Plant Phenolic Compounds Protect the Skin from Airborne Particulate Matter?
  • Y. Boo
  • Chemistry, Medicine
  • Antioxidants
  • 2019
TLDR
Current studies in this field suggest that plant-derived phenolic compounds may have a protective effect on skin exposed to high levels of air pollution. Expand
Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review
TLDR
An overview of curcumin in atherosclerosis prevention is provided and the underlying mechanisms of action of its anti-atherosclerotic effects are disclosed. Expand
Vascular endothelium protective property of curcumin
Correspondence: Serdar Bayrak, MD. Dokuz Eylül Üniversitesi Tıp Fakültesi Kalp ve Damar Cerrahisi Anabilim Dalı, 35340 İnciraltı, İzmir, Türkiye. e-mail: drbayrakserdar@gmail.com 1Department ofExpand

References

SHOWING 1-10 OF 61 REFERENCES
Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells.
TLDR
Examination of the cellular signaling pathways responsible for TiO2 NP-induced endothelial oxidative stress and inflammation indicates that TiO 2 NPs can induce endothelial inflammatory responses via redox-sensitive cellular signaling pathway. Expand
PM2.5 and PM10 Induce the Expression of Adhesion Molecules and the Adhesion of Monocytic Cells to Human Umbilical Vein Endothelial Cells
TLDR
PM2.5 and PM10 induce the activation of HUVEC, leading to monocytic adhesion via the expression of adhesion molecules, suggesting that these particles may participate in the development of inflammatory diseases. Expand
Curcumin and a Morus alba Extract Reduce Pro‐Inflammatory Effects of Resistin in Human Endothelial Cells
TLDR
The results indicate that MA and curcumin target resistin‐induced human endothelial activation partly via antioxidant mechanisms and suggest that they may represent therapeutic agents in vascular disease mediated by resistin. Expand
E-Selectin expression in human endothelial cells exposed to PM10: the role of endotoxin and insoluble fraction.
TLDR
In conclusion, PM10 induces endothelial cell activation, evidenced by enhanced E-Selectin expression, manifested functionally as an increase in monocytic cell adhesion. Expand
Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress.
TLDR
Data indicate that curcumin is a potent inducer of HO-1 in vascular endothelial cells and that increased heme oxygenase activity is an important component inCurcumin-mediated cytoprotection against oxidative stress. Expand
Biologic effects induced in vitro by PM10 from three different zones of Mexico City.
TLDR
Exposure to urban airborne particles from all three zones of Mexico City caused cell death, DNA breakage, and apoptosis, with particles from the north and central zones being the most toxic. Expand
Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stress.
TLDR
The protective effect of curcumin against cisplatin-induced fibrosis and decreased proteins of the TJ and AJ was associated with the prevention of glomerular and proximal tubular superoxide anion production induced by NADPH oxidase activity. Expand
Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine (PM2.5) and coarse particles (PM10-2.5) in outdoor and indoor air.
TLDR
The effective proinflammatory effects of endotoxin on macrophages may upset lung homeostasis while metals-induced cytotoxicity/necrosis may set up inflammation independent of macrophage-derived cytokines. Expand
Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro
TLDR
The adhesion between thrombin-activated platelets and normal BMECs and normal platelets were significantly increased, and this increase could be inhibited by curcumin (30–240 μmol/L) in a concentration-dependant manner. Expand
Toxic effects induced by curcumin in human astrocytoma cell lines
TLDR
Curcumin at 100 µm induced a new type of death cell in astrocytoma cell lines, characterized by a progressive increase in large, non-acidic vesicles devoid of cytoplasmic components and organelles, but that conserved the cell nuclei. Expand
...
1
2
3
4
5
...