Curcumin inhibits UV irradiation‐induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells

@article{Chan2003CurcuminIU,
  title={Curcumin inhibits UV irradiation‐induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells},
  author={W. Chan and C. Wu and Jau-Song Yu},
  journal={Journal of Cellular Biochemistry},
  year={2003},
  volume={90}
}
  • W. Chan, C. Wu, Jau-Song Yu
  • Published 2003
  • Biology, Medicine
  • Journal of Cellular Biochemistry
  • Ultraviolet (UV) light is a strong apoptotic trigger that induces caspase‐dependent biochemical changes in cells. Previously we showed that UV irradiation can activate caspase‐3, and the subsequent cleavage and activation of p21Cdc42/Rac‐activated kinase 2 (PAK2) in human epidermoid carcinoma A431 cells. In this study we demonstrate that curcumin (Cur), the yellow pigment of Curcuma longa with known anti‐oxidant and anti‐inflammatory properties, can prevent UV irradiation‐induced apoptotic… CONTINUE READING
    Anti‐apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells
    • 77

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