Curcumin induces permanent growth arrest of human colon cancer cells: link between senescence and autophagy.

@article{Mosieniak2012CurcuminIP,
  title={Curcumin induces permanent growth arrest of human colon cancer cells: link between senescence and autophagy.},
  author={Grażyna Mosieniak and Marek Adamowicz and Olga Alster and Hubert Jaskowiak and Andrzej A Szczepankiewicz and Grzegorz M. Wilczynski and Iwona Anna Ciechomska and Ewa Sikora},
  journal={Mechanisms of ageing and development},
  year={2012},
  volume={133 6},
  pages={444-55}
}
Curcumin, a natural polyphenol derived from the rhizome of Curcuma longa, is a potent anticancer agent, which restricts tumor cell growth both in vitro and in vivo. Thus far curcumin was shown to induce death of cancer cells. This study reports the induction of cellular senescence of human colon cancer cells HCT116 upon curcumin treatment. The SA-β-galactosidase activation was observed both in p53+/+ and p53-/- cells, however the latter ones were less sensitive to the prosenescent activity of… CONTINUE READING

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