Curcumin induces changes in expression of genes involved in cholesterol homeostasis.

@article{Peschel2007CurcuminIC,
  title={Curcumin induces changes in expression of genes involved in cholesterol homeostasis.},
  author={Dieter Peschel and Ramona Koerting and Norbert Nass},
  journal={The Journal of nutritional biochemistry},
  year={2007},
  volume={18 2},
  pages={113-9}
}
Curcuminoids, the yellow pigments of curcuma, exhibit anticarcinogenic, antioxidative and hypocholesterolemic activities. To understand the molecular basis for the hypocholesterolemic effects, we examined the effects of curcumin on hepatic gene expression, using the human hepatoma cell line HepG2 as a model system. Curcumin treatment caused an up to sevenfold, concentration-dependent increase in LDL-receptor mRNA, whereas mRNAs of the genes encoding the sterol biosynthetic enzymes HMG CoA… CONTINUE READING

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