Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways.

@article{Wu2010CurcuminIA,
  title={Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways.},
  author={S Wu and L M Hang and J. Yang and Hung-Yi Chen and Hui-Yi Lin and J R Chiang and Chi-Cheng Lu and Jiun-Long Yang and Tung-Yuan Lai and Yang-Ching Ko and Jing-Gung Chung},
  journal={Anticancer research},
  year={2010},
  volume={30 6},
  pages={2125-33}
}
It has been reported that curcumin inhibited various types of cancer cells in vitro and in vivo. However, mechanisms of curcumin-inhibited cell growth and -induced apoptosis in human non-small cell lung cancer cells (NCI-H460) still remain unclear. In this study, NCI-H460 cells were treated with curcumin to determine its anticancer activity. Different concentrations of curcumin were used for different durations in NCI-H460 cells and the subsequent changes in the cell morphology, viability, cell… CONTINUE READING
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