Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK.

@article{Weir2007CurcuminIG,
  title={Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK.},
  author={Nathan M. Weir and Karuppaiyah Selvendiran and Vijay Kumar Kutala and Liyue Tong and Shilpa Vishwanath and Murugesan V. S. Rajaram and Susheela Tridandapani and Shrikant Anant and Periannan Kuppusamy},
  journal={Cancer biology & therapy},
  year={2007},
  volume={6 2},
  pages={178-84}
}
Curcumin, a major active component of turmeric, is known to induce apoptosis in several types of cancer cells, but little is known about its activity in chemoresistant cells. Hence, the aim of the present study was to investigate the anticancer properties of curcumin in cisplatin-resistant human ovarian cancer cells in vitro. The results indicated that curcumin inhibited the proliferation of both cisplatin-resistant (CR) and sensitive (CS) human ovarian cancer cells almost equally. Enhanced… CONTINUE READING
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