Curcumin-induced melanoma cell death is associated with mitochondrial permeability transition pore (mPTP) opening.

@article{Qiu2014CurcumininducedMC,
  title={Curcumin-induced melanoma cell death is associated with mitochondrial permeability transition pore (mPTP) opening.},
  author={Ying Qiu and Teng Yu and Wei Wang and Kun Pan and Dongmei Shi and Hui Sun},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={448 1},
  pages={15-21}
}
Here we studied the role of mitochondrial permeability transition pore (mPTP) opening in curcumin's cytotoxicity in melanoma cells. In cultured WM-115 melanoma cells, curcumin induced mitochondrial membrane potential (MPP) decrease, cyclophilin-D (CyPD)-adenine nucleotide translocator 1 (ANT-1) (two mPTP components) mitochondrial association and cytochrome C release, indicating mPTP opening. The mPTP blocker sanglifehrin A (SfA) and ANT-1 siRNA-depletion dramatically inhibited curcumin-induced… CONTINUE READING

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