Curcumin-induced fibroblast apoptosis and in vitro wound contraction are regulated by antioxidants and heme oxygenase: implications for scar formation

@inproceedings{Scharstuhl2009CurcumininducedFA,
  title={Curcumin-induced fibroblast apoptosis and in vitro wound contraction are regulated by antioxidants and heme oxygenase: implications for scar formation},
  author={Alwin Scharstuhl and HAM Mutsaers and SWC Pennings and WA Szarek and F G Russel and F. A. D. T. G. Wagener},
  booktitle={Journal of cellular and molecular medicine},
  year={2009}
}
Fibroblast apoptosis plays a crucial role in normal and pathological scar formation and therefore we studied whether the putative apoptosis-inducing factor curcumin affects fibroblast apoptosis and may function as a novel therapeutic. We show that 25-microM curcumin causes fibroblast apoptosis and that this could be inhibited by co-administration of antioxidants N-acetyl-l-cysteine (NAC), biliverdin or bilirubin, suggesting that reactive oxygen species (ROS) are involved. This is supported by… CONTINUE READING

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