Curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma U266 cells

@article{Park2008CurcuminIC,
  title={Curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma U266 cells},
  author={Juwon Park and Vasudevan Ayyappan and Eunkyung Bae and Chansu Lee and Byung-Su Kim and Byoung Kook Kim and Young-Yuil Lee and Kwang Sung Ahn and Sung-Soo Yoon},
  journal={Molecular Oncology},
  year={2008},
  volume={2}
}
Sensitizing human multiple myeloma cells to the proteasome inhibitor bortezomib by novel curcumin analogs
TLDR
It is shown that the water-soluble analog of curcumin #12, but notCurcumin, in combination with bortezomib could enhance the proteasome-inhibitory effect in multiple myeloma cells.
Curcumin ameliorates the in vitro efficacy of carfilzomib in human multiple myeloma U266 cells targeting p53 and NF-κB pathways.
Curcumin Enhanced Busulfan-Induced Apoptosis through Downregulating the Expression of Survivin in Leukemia Stem-Like KG1a Cells
TLDR
It is demonstrated that CUR could increase the sensitivity of leukemia stem-like KG1a cells to BUS by downregulating the expression of survivin, especially in combination group.
Gambogenic acid synergistically potentiates bortezomib-induced apoptosis in multiple myeloma
TLDR
The data support that a synergistic antitumor activity exists between BTZ and GNA, and provide a rationale for successful utilization of dual BTZ or GNA in MM chemotherapy in the future.
Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK
TLDR
Results suggested that curcumin might enhance the cytotoxicity of PS-341 by interacting with NF-κB, at least in part, through JNK mechanism.
Curcumin Synergistically Enhances the Cytotoxicity of Arsenic Trioxide in U266 Cells by Increasing Arsenic Uptake
TLDR
Curcumin can enhance the killing effects of ATO on U266 by increasing the intracellular arsenic content, which may be related to the upregulation of AQP9 expression.
Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models
TLDR
A novel Mannich-type curcumin derivative, C-150, holds a great promise as a future therapeutic agent in the treatment of leukemia alone or in combination, and was synthesized to improve potency.
Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups
TLDR
It is shown that primary myeloma cells were also sensitive to curcumin, even those displaying del(17p), another poor prognosis factor, and the contribution of anti-apoptotic Bcl-2 family molecules in Curcumin response is unraveled.
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