Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent.

Abstract

Burn wounds are often complicated by bacterial infection, contributing to morbidity and mortality. Agents commonly used to treat burn wound infection are limited by toxicity, incomplete microbial coverage, inadequate penetration, and rising resistance. Curcumin is a naturally derived substance with innate antimicrobial and wound healing properties. Acting by multiple mechanisms, curcumin is less likely than current antibiotics to select for resistant bacteria. Curcumin's poor aqueous solubility and rapid degradation profile hinder usage; nanoparticle encapsulation overcomes this pitfall and enables extended topical delivery of curcumin. In this study, we synthesized and characterized curcumin nanoparticles (curc-np), which inhibited in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in dose-dependent fashion, and inhibited MRSA growth and enhanced wound healing in an in vivo murine wound model. Curc-np may represent a novel topical antimicrobial and wound healing adjuvant for infected burn wounds and other cutaneous injuries.

DOI: 10.1016/j.nano.2014.09.004
02040201520162017
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@article{Krausz2015CurcuminencapsulatedNA, title={Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent.}, author={Aimee E. Krausz and Brandon L. Adler and Vitor Cabral and Mahantesh S Navati and Jessica L Doerner and Rabab A Charafeddine and Dinesh Chandra and Hongying Liang and Leslie Gunther and Alicea Clendaniel and Stacey Harper and Joel Friedman and Joshua Daniel Nosanchuk and Adam Friedman}, journal={Nanomedicine : nanotechnology, biology, and medicine}, year={2015}, volume={11 1}, pages={195-206} }