Curcumin downregulates p38 MAPK-dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells

@article{Tung2016CurcuminDP,
  title={Curcumin downregulates p38 MAPK-dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells},
  author={Chun-Liang Tung and Yi-Jun Jian and Jyh-Cheng Chen and Tai-Jing Wang and Wen-Ching Chen and Hao-yu Zheng and Po-Yuan Chang and Kai-Sheng Liao and Yun-Wei Lin},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2016},
  volume={389},
  pages={657-666}
}
Cisplatin is a well-studied and widely used chemotherapeutic agent and is effective in the treatment of the advanced human non-small cell lung cancer (NSCLC). Curcumin is a yellow pigment derived from the rhizome of Curcuma longa and has been proved to have antioxidant and antitumor properties. XRCC1 is an important scaffold protein involved in base excision repair and plays an important role in the development of lung cancer. In this study, we characterize the role of curcumin in the… CONTINUE READING
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