Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.

@article{Jobin1999CurcuminBC,
  title={Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.},
  author={Christian Jobin and Cynthia A. Bradham and Maria Pia Russo and Booker W O Juma and Acharan S. Narula and David Brenner and Ryan Balfour Sartor},
  journal={Journal of immunology},
  year={1999},
  volume={163 6},
  pages={3474-83}
}
NF-kappa B plays a critical role in the transcriptional regulation of proinflammatory gene expression in various cells. Cytokine-mediated activation of NF-kappa B requires activation of various kinases, which ultimately leads to the phosphorylation and degradation of I kappa B, the NF-kappa B cytoplasmic inhibitor. The food derivative curcumin has been shown to inhibit NF-kappa B activity in some cell types. In this report we investigate the mechanism of action of curcumin on cytokine-induced… CONTINUE READING
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