Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries.

@article{Chai2005CurcuminBH,
  title={Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries.},
  author={Hong Chai and Shaoyu Yan and Peter H Lin and Alan B. Lumsden and Q. -S. Yao and Changyi Johnny Chen},
  journal={Journal of the American College of Surgeons},
  year={2005},
  volume={200 6},
  pages={820-30}
}
BACKGROUND HIV protease inhibitor ritonavir (RTV) is associated with many cardiovascular complications and causes vascular dysfunction through oxidative stress. In the present study, we determined the effects of RTV and curcumin (a pigment derived from turmeric) on porcine coronary arteries. STUDY DESIGN Artery rings were incubated with 15 microM concentration of RTV and curcumin (5 or 10 microM) for 24 hours. Vasomotor function was studied with a myograph tension system. Endothelial nitric… CONTINUE READING