Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice.

@article{He2012CurcuminAN,
  title={Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice.},
  author={Hui-Jun He and Guoyu Wang and Yuan Gao and Wen-Hua Ling and Zhi-Wen Yu and Tian-ru Jin},
  journal={World journal of diabetes},
  year={2012},
  volume={3 5},
  pages={94-104}
}
AIM To investigate the signaling mechanism of anti-oxidative action by curcumin and its impact on glucose disposal. METHODS Male C57BL/6J mice were fed with either a normal diet (n = 10) or a high fat diet (HFD) (n = 20) to induce obesity and insulin resistance. After 16 wk, 10 HFD-fed mice were further treated with daily curcumin oral gavage at the dose of 50 mg/kg body weight (BW) (HFD + curcumin group). After 15 d of the curcumin supplementation, an intraperitoneal glucose tolerance test… CONTINUE READING

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