Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression.

@article{Tu2012CurcuminAC,
  title={Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression.},
  author={Chuan-Tao Tu and Bing Han and Qun-yan Yao and Yi-an Zhang and Hong-chun Liu and Shun-cai Zhang},
  journal={International immunopharmacology},
  year={2012},
  volume={12 1},
  pages={151-7}
}
Curcumin has antiviral, antioxidant, and anti-inflammatory properties. However, the hepatoprotective effects and molecular mechanisms of curcumin on acute liver injury have not been carefully examined. The aims of this study were to examine the anti-inflammatory effect of curcumin on Concanavalin A (Con A) induced hepatitis, and to elucidate its underlying molecular mechanisms in mice. Mice received curcumin (200 mg/kg body weight) by gavage before Con A intravenous administration. We found… CONTINUE READING