Curcumin as a modulator of oxidative stress during storage: a study on plasma.

@article{Carl2014CurcuminAA,
  title={Curcumin as a modulator of oxidative stress during storage: a study on plasma.},
  author={H. Carl and Ahuja Chandni and K. Neha and S. Trishna and R. Vani},
  journal={Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis},
  year={2014},
  volume={50 2},
  pages={
          288-93
        }
}
  • H. Carl, Ahuja Chandni, +2 authors R. Vani
  • Published 2014
  • Chemistry, Medicine
  • Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
BACKGROUND Plasma reflects the situations of oxidative stress in blood. Curcumin as an additive in storage solutions is not explored. MATERIALS AND METHODS Blood was drawn from male Wistar rats (4 months old) and stored over a period of 20 days at 4 °C in CPDA-1. Plasma was isolated from stored blood at regular intervals. Oxidative stress markers were analyzed in controls and experimental samples (with curcumin 10mM, 30 mM and 60mM). RESULTS Antioxidant enzymes and sulfhydryls ameliorated… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
Influence of Antioxidants on the Quality of Stored Blood
TLDR
It is suggested that antioxidants given to blood donors can improve red cell storage parameters by reducing cell damage caused by free radicals. Expand
Advanced oxidation protein products as a novel marker of oxidative stress in uremia.
TLDR
The measurement of AOPP is proposed as a reliable marker to estimate the degree of oxidant-mediated protein damage in uremic patients and to predict the potential efficacy of therapeutic strategies aimed at reducing such an oxidative stress. Expand
Concentration dependent antioxidant/pro-oxidant activity of curcumin studies from AAPH induced hemolysis of RBCs.
TLDR
It is concluded that curcumin exhibits both antioxidant/pro-oxidant activity, in a concentration dependent manner. Expand
Cytotoxic Effects of Curcumin At Various Concentrations and Role of Curcumin on Lipid Peroxidation and Activities of Antioxidant Enzymes of the Rat Peripheral Blood Lymphocytes
Abstract 4933 Background: Curcumin (diferuloylmethane) is an active ingredient of turmeric and has been suggested to have antiproliferative, pro-oxidant and cytotoxic effects (Das R, Apoptosis 2008).Expand
Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha
TLDR
It is suggested that L-carnitine could protect HL7702 cells against oxidative stress through the antioxidative effect and the regulation of PPAR-alpha also play an important part in the protective effect. Expand
The impact of simultaneous intoxication with agrochemicals on the antioxidant defense system in rat
TLDR
The increase in oxidative stress and damage biomarker levels, as well as the alteration of the antioxidant defence system decreased testosterone, FSH and LH levels in the plasma of pesticide-treated rats, and should be considered indicative of involuntary exposure to residual agrochemicals. Expand
The efficacy of erythrocytes isolated from blood stored under blood bank conditions.
  • Vani Rajashekharaiah, A. Koshy, +8 authors Vinay Kumar
  • Biology, Medicine
  • Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • 2012
TLDR
The results indicate that the erythrocytes are capable of attenuating ROS with 2 weeks of storage, which clearly indicates that prolonged storage may result in the onset of ERYthrocyte deterioration. Expand
Markers of oxidative stress in erythrocytes and plasma during aging in humans
TLDR
The aging process is discussed and the importance of some reliable markers of oxidative stress which may be used as biomarkers of the aging process are focused on. Expand
Antioxidant defenses and lipid peroxidation in human blood plasma.
  • B. Frei, R. Stocker, B. Ames
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1988
TLDR
The data suggest that in states of leukocyte activation and other types of acute or chronic oxidative stress such a simple regimen as controlled ascorbate supplementation could prove helpful in preventing formation of lipid hydroperoxides, some of which cannot be detoxified by endogenous plasma activities and thus might cause damage to critical targets. Expand
Decreasing Oxidative Stress with Choline and Carnitine in Women
Objective: Fatty acid oxidation is predominantly a mitochondrial event, which is enhanced by dietary choline and carnitine supplementation resulting in extra reactive oxygen species (ROS) load. TheExpand
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