Curcumin and quercetin trigger apoptosis during benzo(a)pyrene-induced lung carcinogenesis

  title={Curcumin and quercetin trigger apoptosis during benzo(a)pyrene-induced lung carcinogenesis},
  author={Praveen Balakrishnan Nair and Anshoo Malhotra and Devinder Kumar Dhawan},
  journal={Molecular and Cellular Biochemistry},
The aim of the present study was to assess the cumulative effects of curcumin and quercetin in inducing apoptosis during benzo(a)pyrene (BP) (100 mg/Kg body weight)-induced lung carcinogenesis in mice. BP treatment resulted in a significant increase in the protein expression of Bcl-2 whereas expression of Bax was significantly decreased. Further, BP treatment brought about a significant decrease in the activities of caspase 3, caspase 9 as well as the number of apoptotic cells. Interestingly… CONTINUE READING
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