Curcumin analogues inhibit phosphodiesterase-5 and dilate rat pulmonary arteries.

  title={Curcumin analogues inhibit phosphodiesterase-5 and dilate rat pulmonary arteries.},
  author={Oraya Kruangtip and Krongkarn Chootip and Prapapan Temkitthawon and Kanokwan Changwichit and Thipphawan Chuprajob and Chatchawan Changtam and Apichart Suksamrarn and Nantaka Khorana and Charles N Scholfield and Kornkanok Ingkaninan},
  journal={The Journal of pharmacy and pharmacology},
  volume={67 1},
OBJECTIVES Phosphodiesterase (PDE)-5 inhibitors are useful as vasodilators for the treatment of pulmonary arterial hypertension. We aimed to study curcumin analogues for PDE5 inhibitory activity and vasorelaxation of rat pulmonary arteries. METHODS Three natural curcuminoids (1-3) and six synthetic analogues (4-9) were tested for PDE5 and PDE6 inhibitory activities using enzymatic radioassay. Their vasorelaxation was measured using freshly isolated segments of rat pulmonary artery and aorta… CONTINUE READING