Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro.

@article{Chiang2015CurcuminAG,
  title={Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro.},
  author={I-Tsang Chiang and Wei‐Shu Wang and Hsin-Chung Liu and Su-Tso Yang and N. Tang and Jing-Gung Chung},
  journal={Oncology reports},
  year={2015},
  volume={34 4},
  pages={
          1853-74
        }
}
Lung cancer is the most common cause of cancer mortality and new cases are on the increase worldwide. However, the treatment of lung cancer remains unsatisfactory. Curcumin has been shown to induce cell death in many human cancer cells, including human lung cancer cells. However, the effects of curcumin on genetic mechanisms associated with these actions remain unclear. Curcumin (2 µM) was added to NCI-H460 human lung cancer cells and the cells were incubated for 24 h. Total RNA was extracted… Expand
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