Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway.

@article{Soetikno2013CurcuminAO,
  title={Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway.},
  author={Vivian Soetikno and Flori R. Sari and Arun Prasath Lakshmanan and Somasundaram Arumugam and Meilei Harima and Kenji Suzuki and Hiroshi Kawachi and Kenichi Watanabe},
  journal={Molecular nutrition & food research},
  year={2013},
  volume={57 9},
  pages={1649-59}
}
SCOPE We hypothesized that curcumin, by increasing the expression of nuclear factor-erythroid-2-related factor 2 (Nrf2), could reduce oxidative stress, inflammation, and renal fibrosis in remnant kidney. METHODS AND RESULTS Sprague-Dawley rats were subjected to 5/6 nephrectomy and randomly assigned to untreated (Nx), curcumin-treated (75 mg/kg/day, orally), and telmisartan-treated groups (10 mg/kg/day, orally; as positive control). Sham-operated rats also served as controls. Five/sixth… CONTINUE READING
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