Curcumin acts via transient receptor potential vanilloid-1 receptors to inhibit gut nociception and reverses visceral hyperalgesia.

@article{Zhi2013CurcuminAV,
  title={Curcumin acts via transient receptor potential vanilloid-1 receptors to inhibit gut nociception and reverses visceral hyperalgesia.},
  author={Lida Zhi and Lauren Bin Dong and Dae-Jong Kong and Biying Sun and Qing-wen Sun and David Grundy and G-X Zhang and Weifang Rong},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2013},
  volume={25 6},
  pages={
          e429-40
        }
}
BACKGROUND An antinociceptive effect has been reported for curcumin in animal models and in humans, but the molecular mechanisms of curcumin's effect remain undefined. In this study, we explored the possibility that curcumin inhibit visceral nociception via antagonizing the transient receptor potential vanilloid-1 (TRPV1) receptor. METHODS The effects of curcumin were explored using two experimental models: viscero-motor response (VMR) to colorectal distension (CRD) in rats and jejunal… CONTINUE READING
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