Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.

@article{Balogun2003CurcuminAT,
  title={Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.},
  author={Elisabeth Balogun and Martha Hoque and Pengfei Gong and Erin Killeen and Colin J. Green and R. Foresti and Jawed Alam and Roberto Motterlini},
  journal={The Biochemical journal},
  year={2003},
  volume={371 Pt 3},
  pages={887-95}
}
The transcription factor Nrf2, which normally exists in an inactive state as a consequence of binding to a cytoskeleton-associated protein Keap1, can be activated by redox-dependent stimuli. Alteration of the Nrf2-Keap1 interaction enables Nrf2 to translocate to the nucleus, bind to the antioxidant-responsive element (ARE) and initiate the transcription of genes coding for detoxifying enzymes and cytoprotective proteins. This response is also triggered by a class of electrophilic compounds… CONTINUE READING