Curcumin Treatment Suppresses IKKβ Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study

@article{Kim2011CurcuminTS,
  title={Curcumin Treatment Suppresses IKK$\beta$ Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study},
  author={Suejung G Kim and Mysore S. Veena and Saroj K. Basak and Eugene S. Han and Tracey Tajima and David Gjertson and Joshua Starr and Ofer Eidelman and Harvey B Pollard and Meera Srivastava and Eri S. Srivatsan and Marilene B. Wang},
  journal={Clinical Cancer Research},
  year={2011},
  volume={17},
  pages={5953 - 5961}
}
Purpose: To determine whether curcumin would inhibit IκB kinase β (IKKβ) kinase activity and suppress expression of proinflammatory cytokines in head and neck squamous cell carcinoma cancer (HNSCC) patients. Experimental Design: Saliva was collected before and after subjects chewed curcumin tablets. Protein was extracted and IKKβ kinase activity measured. Interleukin (IL)-6 and IL-8 levels in the salivary supernatants were measured by ELISA. IL-6, IL-8, and other interleukin were also measured… Expand
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