Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma.

@article{Tsai2015CurcuminSP,
  title={Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma.},
  author={Cheng-Fang Tsai and Tsung-Hua Hsieh and Jau-nan Lee and Chia-Yi Hsu and Yu-Chih Wang and K. K. Kuo and H L Wu and Chien-Chih Chiu and Eing-Mei Tsai and Po-Lin Kuo},
  journal={Journal of agricultural and food chemistry},
  year={2015},
  volume={63 48},
  pages={10388-98}
}
Recent evidence indicating that phthalates promote cancer development, including cell proliferation, migration, and invasion, has raised public health concerns. Here, we show that bis(2-ethylhexyl) phthalate promotes the migration, invasion, and epithelial-mesenchymal transition of hepatocellular carcinoma cells. In addition, bis(2-ethylhexyl) phthalate increased the proportion of cancer stem cell (CSC)-like cells and stemness maintenance in vitro as well as tumor growth and metastasis in vivo… CONTINUE READING
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