Curcumin Reactivates Silenced Tumor Suppressor Gene RARβ by Reducing DNA Methylation.


Reactivation of tumor suppressor genes by nontoxic bioactive food component represents a promising strategy for cancer chemoprevention. Retinoic acid receptor β (RARβ), one member of the RAR receptor family, is considered as a tumor suppressor. Reduced expression of RARβ has been reported in lung cancer and other solid tumors. DNA hypermethylation of the… (More)
DOI: 10.1002/ptr.5373