Curcumin Promotes KLF5 Proteasome Degradation through Downregulating YAP/TAZ in Bladder Cancer Cells

@inproceedings{Gao2014CurcuminPK,
  title={Curcumin Promotes KLF5 Proteasome Degradation through Downregulating YAP/TAZ in Bladder Cancer Cells},
  author={Yang Gao and Qi Shi and Shan Xu and Chong Du and Liang Liang and Kaijie Wu and Ke Wang and Xinyang Wang and Luke Chang and Dalin He and Peng Guo},
  booktitle={International journal of molecular sciences},
  year={2014}
}
KLF5 (Krüppel-like factor 5) plays critical roles in normal and cancer cell proliferation through modulating cell cycle progression. In this study, we demonstrated that curcumin targeted KLF5 by promoting its proteasome degradation, but not by inhibiting its transcription in bladder cancer cells. We also demonstrated that lentivirus-based knockdown of KLF5 inhibited cancer cell growth, while over-expression of a Flag-tagged KLF5 could partially reverse the effects of curcumin on cell growth and… CONTINUE READING
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