Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy

@inproceedings{Lee2011CurcuminIE,
  title={Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy},
  author={Jen-Yi Lee and Yee-Ming Lee and G C Chang and Sung-Liang Yu and Wan-Yu Hsieh and Jeremy J. W. Chen and H. W. Chen and Pan-Chyr Yang},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Non-small cell lung cancer (NSCLC) patients with L858R or exon 19 deletion mutations in epidermal growth factor receptor (EGFR) have good responses to the tyrosine kinase inhibitor (TKI), gefitinib. However, patients with wild-type EGFR and acquired mutation in EGFR T790M are resistant to gefitinib treatment. Here, we showed that curcumin can improve the efficiency of gefitinib in the resistant NSCLC cells both in vitro and in vivo models. METHODS/PRINCIPAL FINDINGS After screening… CONTINUE READING
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