Curcumin Could Prevent the Development of Chronic Neuropathic Pain in Rats with Peripheral Nerve Injury☆

Younghoon Jeon, Chae-Eun Kim, +5 authors Woonyi Baek
Published 2013 in
Current therapeutic research, clinical and…

Abstract

BACKGROUND Peripheral nerve injury results in chronic neuropathic pain characterized by allodynia and/or spontaneous pain. It has been suggested that activation of mitogen-activated protein kinases such as extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) contribute to the neuropathic pain. OBJECTIVES We investigated if… (More)

DOI: 10.1016/j.curtheres.2012.10.001

A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury

Poornima Ramburrun, Pradeep Kumar, Yahya E Choonara, Divya Bijukumar, Lisa C du Toit, Viness Pillay
BioMed research international
2014

Curcumin Could Prevent the Development of Chronic Neuropathic Pain in Rats with Peripheral Nerve Injury☆

Abstract

Topics

2 Figures and Tables

Cited By

Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats.

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Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats

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A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury

References

Mechanisms and treatment of neuropathic pain.

Nitric oxide and pain: 'Something old, something new'.

Protein kinases as potential targets for the treatment of pathological pain.

Reversal of ERK activation in the dorsal horn after decompression in chronic constriction injury.

A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling

Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.

GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain.

Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer—Part 2

Spinal NMDA receptor phosphorylation correlates with the presence of neuropathic signs following peripheral nerve injury in the rat.

Slides referencing similar topics

Curcumin Could Prevent the Development of Chronic Neuropathic Pain in Rats with Peripheral Nerve Injury☆

Abstract

Topics

2 Figures and Tables

Cited By

Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats.

Mechanisms of Peripheral Nerve Injury – What to Treat, When to Treat

Oral administration of curcumin attenuates visceral hyperalgesia through inhibiting phosphorylation of TRPV1 in rat model of ulcerative colitis

Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects.

Curcumin upregulates S100 expression and improves regeneration of the sciatic nerve following its complete amputation in mice

Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease.

Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats

Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis

Multiple Biological Actions of Curcumin in the Management of Diabetic Foot Ulcer Complications: A Systematic Review

A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury

References

Mechanisms and treatment of neuropathic pain.

Nitric oxide and pain: 'Something old, something new'.

Protein kinases as potential targets for the treatment of pathological pain.

Reversal of ERK activation in the dorsal horn after decompression in chronic constriction injury.

A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling

Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.

GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain.

Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer—Part 2

Spinal NMDA receptor phosphorylation correlates with the presence of neuropathic signs following peripheral nerve injury in the rat.

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