• Corpus ID: 212521611

Curcumin Analysis and Cytotoxic Activities of Some Curcuma xanthorrhiza Roxb

@inproceedings{Nurcholis2016CurcuminAA,
  title={Curcumin Analysis and Cytotoxic Activities of Some Curcuma xanthorrhiza Roxb},
  author={Waras Nurcholis and Laksmi Ambarsari and Edy Djauhari Purwakusumah},
  year={2016}
}

• W. Nurcholis, L. Ambarsari, Edy Djauhari Purwakusumah
• Published 2016

Curcumin in rhizome of Curcuma xanthorrhiza Roxb. have potential pharmacological activities. In the present study, curcumin contents and cytotoxic activities of some C. xanthorrhiza accessions were evaluated. The curcumin contents were analyzed by HPLC. Cytotoxic studies using brine shrimp lethality test and Vero and MCF-7 cell line cultures were carried out. The curcumin content varied between 24.70 ± 10.72 mg g in accession of SG (Sragen) to 54.09 ± 3.48 mg g in accession of WG (Wonogiri). All accessions were found to be effective in general toxicity against brine shrimps. Accession of WG showed in vitro cytotoxicity against Vero and MCF-7 cell line. Accession of WG indicated the possibility of selecting high quality clone for curcumin production and anticancer in MCF-7 cell line.