Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells.

@article{Sun2008CurcuminA,
  title={Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells.},
  author={Michael A Sun and Zeev Estrov and Yuan Ji and Kevin R. Coombes and David C H Harris and Razelle Kurzrock},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 3},
  pages={464-73}
}
BACKGROUND A major challenge in cancer chemotherapy has been developing safe and clinically efficacious chemotherapeutic agents. With its low toxicity profile, curcumin (diferuloylmethane), a naturally occurring flavinoid derived from the rhizome of Curcuma longa, has great promise. In vitro and in vivo preclinical studies have shown its inhibitory anticancer, antioxidant, anti-inflammatory, antiproliferative, and proapoptotic activities. The multiple mechanisms of the antitumor effect of… CONTINUE READING