Curcumin (Diferuloylmethane) Downregulates the Constitutive Activation of Nuclear Factor κB and IκBα Kinase in Human Multiple Myeloma Cells Leading to Suppression of Proliferation and Induction of Apoptosis

@inproceedings{Bharti2002CurcuminD,
  title={Curcumin (Diferuloylmethane) Downregulates the Constitutive Activation of Nuclear Factor κB and IκBα Kinase in Human Multiple Myeloma Cells Leading to Suppression of Proliferation and Induction of Apoptosis},
  author={Alok Chandra Bharti and Nazareno Donato and Sujay Singh and Bharat Bhushan Aggarwal},
  year={2002}
}
Because of the central role of the nuclear transcription factor NF-B in cell survival and proliferation in human multiple myeloma (MM), we explored the possibility of using it as a target for MM treatment by using curcumin (diferuloylmethane) an agent known to have very little or no toxicity in humans. We found that NF-B was constitutively active in all human MM cell lines examined and that curc umin, a chemopreventive agent, downregulated NF-B in all cell lines as indicated by electrophoretic… CONTINUE READING
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