Curcumin's Biphasic Hormetic Response on Proteasome Activity and Heat‐Shock Protein Synthesis in Human Keratinocytes

@article{Ali2006CurcuminsBH,
  title={Curcumin's Biphasic Hormetic Response on Proteasome Activity and Heat‐Shock Protein Synthesis in Human Keratinocytes},
  author={Rehab E Ali and Suresh I. S. Rattan},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1067}
}
Abstract:  Curcumin (diferuloylmethane), is a component of the yellow powder prepared from the roots of Curcuma longa (Zingiberaceae), also known as tumeric or turmeric. It is widely cultivated and used as a food ingredient in tropical areas of Asia and Central America. Treatment of mid‐passage human epidermal keratinocytes with curcumin resulted in a biphasic hormetic dose–response with respect to proteasome activity. Curcumin treatment (up to 1 μM for 24 h) increased chymotrypsin‐like… 

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