Curcumin: a double hit on malignant mesothelioma.

  title={Curcumin: a double hit on malignant mesothelioma.},
  author={Jill M. Miller and Joyce K. Thompson and Maximilian B Macpherson and Stacie L. Beuschel and Catherine M Westbom and Mutlay Sayan and Arti Shukla},
  journal={Cancer prevention research},
  volume={7 3},
Inflammation is a key mediator in the development of malignant mesothelioma, which has a dismal prognosis and poor therapeutic strategies. Curcumin, a naturally occurring polyphenol in turmeric, has been shown to possess anticarcinogenic properties through its anti-inflammatory effects. Inflammasomes, a component of inflammation, control the activation of caspase-1 leading to pyroptosis and processing of proinflammatory cytokines, interleukin (IL)-1β and IL-18. In the present study, we… CONTINUE READING
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