Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit.

@article{Lavoie2009CurcuminQA,
  title={Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit.},
  author={Suzie Lavoie and Ying Chen and Timothy P. Dalton and Ren{\'e} Gysin and M. Cu{\'e}nod and Pascal Steullet and Kim Q Do},
  journal={Journal of neurochemistry},
  year={2009},
  volume={108 6},
  pages={1410-22}
}
A decrease in GSH levels, the main redox regulator, can be observed in neurodegenerative diseases as well as in schizophrenia. In search for substances able to increase GSH, we evaluated the ability of curcumin (polyphenol), quercetin (flavonoid), and tert-butylhydroquinone (tBHQ) to up-regulate GSH-synthesizing enzymes. The gene expression, activity, and… CONTINUE READING