Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells.

@article{Chen2007CurcuminBH,
  title={Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells.},
  author={Yan Chen and Wenxiu Shu and Weihua Chen and Quansheng Wu and Hongli Liu and Guohui Cui},
  journal={Basic & clinical pharmacology & toxicology},
  year={2007},
  volume={101 6},
  pages={427-33}
}
Curcumin, the active chemical of the Asian spice turmeric, exhibits anticancer activity in several human cancer cell lines. We previously have proved that curcumin was a new member of the histone deacetylases (HDAC) inhibitors, while constitutive nuclear factor kappa B (NF-kappaB) is believed to be a crucial event for enhanced proliferation and survival of malignant cells. Here, we investigate the effect of curcumin on the activation of NF-kappaB signal molecule in Raji cells to explore its… CONTINUE READING