Curculigoside A attenuates experimental cerebral ischemia injury in vitro and vivo.

@article{Jiang2011CurculigosideAA,
  title={Curculigoside A attenuates experimental cerebral ischemia injury in vitro and vivo.},
  author={Wei Jiang and Feng Fu and J Tian and Haibo Zhu and Jian Hou},
  journal={Neuroscience},
  year={2011},
  volume={192},
  pages={572-9}
}
Recent studies have demonstrated nuclear factor-κB (NF-κB) and high-mobility group box1 (HMGB1) associated with the pathophysiology of cerebral ischemia. We isolated Curculigoside A, the major bioactive compound present in Curculigo orchioides. The objectives of this study were to determine the effects of Curculigoside A on cultured neuronal cell line, SH-SY5Y in vitro and experimental ischemic stroke in vivo. For oxygen-glucose deprivation and tumor necrosis factor-α (TNF-α) stimulated SH-SY5Y… CONTINUE READING
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