Curative effect of selenium against indomethacin-induced gastric ulcers in rats.

@article{Kim2011CurativeEO,
  title={Curative effect of selenium against indomethacin-induced gastric ulcers in rats.},
  author={Jeong-Hwan Kim and B. Kim and H Kwon and Soo-Wan Nam},
  journal={Journal of microbiology and biotechnology},
  year={2011},
  volume={21 4},
  pages={400-4}
}
Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions. In this study, we investigated the effect of selenium on gastric mucosal lesions in rats. To confirm the curative effect of selenium against indomethacin-induced gastric ulcers, gastric ulcers were induced by oral administration of 25 mg/kg indomethacin, and then different doses (10, 50, and 100 microgram/kg of body weight) of selenium or vehicle were treated by oral gavage for 3 days… CONTINUE READING

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