Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights

Transcription factors (TFs) play a central role in regulating gene expression by interacting with cis-regulatory DNA elements associated with their target genes. Recent surveys have examined the DNA binding specificities of most Saccharomyces cerevisiae TFs, but a comprehensive evaluation of their data has been lacking. We analyzed in vitro and in vivo TF… CONTINUE READING